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Introduction: Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon except in Asiansmaking it difficult to assemble an adequate study sample.

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In this study meet someone Cary NC conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cancer. Methods: We conducted a two-phase discovery and replication genome-wide association study in never-smokers of European descent. We further augmented the sample by performing a meta-analysis with never-smokers from the recent OncoArray study, which resulted albanian dating Pasadena TX a total of cases and controls.

We also compare our findings with those in smokers with lung cancer. : We detected three genome-wide statistically ificant single nucleotide polymorphisms rs odds ratio [OR]: 0. All three mapped to Chromosome 5 CLPTM1L-TERT region, ly shown to be associated with lung cancer risk in chinese Tallahassee FL women dating and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate.

Conclusions: We found that genetic susceptibility to lung cancer in never-smokers is associated to genetic variants with pan-cancer risk effects. The comparison with smokers shows that top variants ly shown to be associated with lung cancer risk only confer risk in the presence of tobacco exposure, underscoring the importance of gene-environment interactions in the etiology of this disease.

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Keywords: Genetic susceptibility; Genome-wide association study; Lung cancer; Never smokers. All rights reserved. The authors declare that none of them has a conflict of interest.

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Frequency: Monthly Speed dating Wichita Falls TX Daily. Which day? Send at most: 1 item 5 items 10 items 20 items 50 items items items. Send even when there aren't any new. Optional text in :. Save Cancel. Create a file for external citation management software Create file Cancel. of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Abstract Introduction: Inherited susceptibility to lung cancer risk in never-smokers is poorly understood.

Conflict of interest statement The authors declare that none of them has a conflict of interest. Figures Figure 1. Manhattan plot of the association….

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Figure 1. Manhattan plot of the association analysis of lung cancer in European ancestry never…. Manhattan plot of the association analysis of lung cancer in European ancestry Asheville NC sex online free smokers performed tly in the discovery set and the OncoArray samples. The x-axis is chromosomal position, and the y-axis is the statistical ificance on a —log 10 scale.

Figure 2. Regional association plots for smokers….

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Regional association plots for smokers red line and never smokers blue line in…. To aid visual representation we selected the 10 closest SNP and computed average —log 10 P- values. See this image and copyright information in PMC. Free chat line number in Miami Florida FL articles Role of 5p Wang Y, et al. Epub Dec 2. PMID: Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p a pooled analysis from the International Lung Cancer Consortium. Truong T, et al. J Natl Cancer Inst.

Epub Jun Novel genetic variants in the chromosome 5p Pande M, et al. Epub Jul Systematic Review of Genetic Variation in Chromosome 5p Kachuri L, et al. Cancer Epidemiol Biomarkers Prev. Epub Aug PMID: Review.

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Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. Mocellin S, et al. Epub Apr See all similar articles.

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Cited by 2 articles DCBLD1 is associated with the integrin aling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma. Cardin GB, et al. Sci Rep. Liang M, et al. BMC Pulm Med. Publication types Research Support, Non-U. Gov't Actions. Female Actions. Genetic Predisposition to Disease Actions.

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Genetic Variation Actions. Humans Actions. Middle Aged Actions. Polymorphism, Single Nucleotide Actions. Risk Factors Actions.

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Membrane Proteins Actions. TERT protein, human Actions. Telomerase Actions.